Antiepileptic Drugs - Table 3
AEDs that may aggravate some epileptic syndromes
|
Drug
|
Syndrome
|
Type of seizure worsening/precipitation
|
|
Benzodiazepines (Valium®)
|
Lennox-Gastaut syndrome
|
Tonic seizures
|
|
Carbamazepine (Tegretol®)
|
Absence epilepsy
Juvenile myoclonic epilepsy
Progressive myoclonus epilepsy
Rolandic epilepsy
|
Absences, myoclonus
Myoclonic seizures
Myoclonus
CSWS, Negative myoclonus
|
|
Gabapentin (Neurontin®)
|
Absence epilepsy
Epilepsies with myoclonus
|
Absences
Myoclonus
|
|
Vigabatrin (Sabril®)
|
Absence epilepsy
Epilepsies with myoclonus
Focal cortical dysplasia
|
Absences
Myoclonus
Myoclonic seizures
|
|
Lamotrigine (Lamictal®)
|
Severe myoclonic epilepsy
Juvenile myoclonic epilepsy
|
At high dosage
Myoclonic seizures
|
|
Phenobarbital (Luminale®)
|
Absence epilepsy
|
At high doses, absences
|
|
Phenytoin (Dintoina®)
|
Absence epilepsy
Progressive myoclonus epilepsy
|
Absences
Cerebellar syndrome
|
|
Tiagabine (Gabitril®)
|
Idiopathic Generalized Epilepsy
|
Absence, Myoclonic seizures
|
Legend: CSWS = continuous spikes and waves during slow sleep; BDZs = benzodiazepines; CBZ = carbamazepine; GPT = gabapentin; GVG = gamma vinyl-GABA; LTG = lamotrigine; PB = phenobarbitone; PHT = phenytoin; TGB = tiagabine.